Trifluoroacetic acid → HCID 22852538, compound

Participants

Reaction Steps

In ethanol (8.5 ml) was dissolved (3R)-2-(2,4-difluorophenyl)-1-(1-imidazolyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-2-butanol (1.7 g) followed by addition of trifluoroacetic acid (8.5 ml) at 0° C. After 10 minutes, the temperature was adjusted to 20° C. and the mixture was allowed to stand for 1 hour. The reaction mixture was then concentrated under reduced pressure and the residue was subjected to silica gel chromatography (2 cm×10 cm) using methanol-methylene chloride (1:9) as the eluent. The desired fraction was concentrated to give (3R)-2-(2,4-difluorophenyl)-1-(1-imidazolyl)-2,3-butanediol (1.7 g).

Provenance & Evidence