反应详情

In ethyl acetate (10 ml) was dissolved (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol (compound 43, 0.2 g) followed by addition of 4 N HCl-ethyl acetate (1 ml). The mixture was concentrated under reduced pressure to about 1 ml, whereupon crystals separated out. Then, ethyl ether (2 ml) was added and the mixture was filtered to give compound 43 hydrochloride (0.15 g) as colorless needles. m.p. 155°-162° C.

1. concentrationThe mixture was concentrated under reduced pressure to about 1 ml, whereupon crystals
2. customseparated out
3. additionThen, ethyl ether (2 ml) was added
4. filtrationthe mixture was filtered