反应详情

A solution (10 ml) of diethyl N-hydroxyaspartate (9.4% solution, 7.8 g, 3.6 mmol) in ethanol was fed in a quartz column (1 inch ID) containing glass beads (3 inches long) at 200° C. at the rate of 0.2 ml per minute along with nitrogen at a rate of 1000 ml per minute. The vaporized material escaping at the end of quartz column was collected using a dry-ice trap. The condensate (0.35 g) was analyzed by GLC. The analysis found that the reaction gave diethyl 2-aminomaleate in about 34.5% yield.

1. additioncontaining glass beads (3 inches long) at 200° C. at the rate of 0.2 ml per minute along with nitrogen at a rate of 1000 ml per minute
2. customwas collected