Cyclopentanepropanoic acid → HCID 56994837, compound

Participants

Reaction Steps

The product from Example 7, Step II was condensed with 3-cyclopentylpropionic acid according to Procedure E (Example 7, Step III). The product was recrystallized from EtOAc-hexane to give N-[4-[4-[(2-Cyclopentylethylcarbonyl)ethylamino]-1-hydroxybutyl]phenyl]methanesulfonamide (42.8%): mp 101°-102° C.; NMR (CDCl3) δ1.13 (m, 5H), 1.63 (m, 13H), 2.3 (m, 2H), 2.99 (d, 3H), 3.39 (m, 4H), 4.72 (m, 1H), 7.07 (s, 1H), 7.24 (m, 4H); MS m/z (relative intensity) 410 (M+, 2.8), 392 (3.2), 331 (11.5), 223 (29.0), 207 (6.3), 200 (2.9), 189 (19.4); IR (Nujol) 3397, 3190, 1591 cm-1. Anal. calc'd for C21H34N2O4S: C, 61.43 ; H, 8.35; N, 6.82; S, 7.81. Found: C, 61.21; H, 8.56; N, 6.59; S, 7.77.

Provenance & Evidence