Sodium Bicarbonate → HCID 15294464, compound

Participants

Reaction Steps

According to Procedure B (Example 17, Step IV), a stirred mixture of N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide (Example 7, Step II) and sodium bicarbonate in acetonitrile was allowed to react with 1-cyclopropyl-5-iodopentane (Step II) to give N-[4-[4-[ethyl(5-cyclopropylpentyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide, a compound of Formula I'. A mixture of this compound and 0.5 equivalents of fumaric acid was crystallized from acetone to give the titled product, mp 127°-128° C. Anal. calc'd for C23H38N2O5S: C, 60.76; H, 8.42; N, 6.16; S, 7.05. Found: C, 60.66; H, 8.30; N, 6.17; S, 7.04.

Provenance & Evidence