HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 14817095, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,3-Difluorophenol | HCID 80879 | — |
| Reactant | 6-Cyclopropylhexan-1-ol | HCID 14817094 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14817095 | HCID 14817095 | 99.3% |
Reaction Steps
3.9 g of NaH (60% in oil) and 20 g of 6-cyclopropyl-hexanol were added to a solution of 8.5 g of difluoro-phenol in 100 ml of DMF. After a reaction time of 24 hours at room temperature, the solution was poured onto ice and extracted with CH2Cl2. After drying (Na2SO4) and removal of the solvent by distillation, 16.5 g of 6-cyclopropylhexyloxy-2,3-difluorobenzene were obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05407599 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-f985eccb90b04e28aa59a2a73d70849b |
| Source note | uspto-grants-1995_04 |