1,5-Diazabicyclo(5,4,0)undec-5-ene → HCID 178465982, compound

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Reaction Steps

1.63 ml of 1,5-diazabicyclo(5.4.0)undec-5-ene followed by 3.15 g of N-(4-cyclopropyl-6-ethoxy-triazin-2-yl)-phenylcarbamate are added to a solution of 2.24 g of 3-difluoromethoxypyridin-2-yl-sulfonamide in 40 ml of acetonitrile. The reaction mixture is stirred for 45 minutes at room temperature and then concentrated using a rotary evaporator. The oily residue is triturated with 8 ml of 2N hydrochloric acid and diluted with 10 ml of water. The crystal mass is filtered off, washed with water and diethyl ether and dried, yielding 4.05 g of N-(3-difluoromethoxypyridine-2-sulfonyl)-N'-(4-cyclopropyl-6-ethoxy-triazin-2-yl)-urea having a melting point of 144°-145° C.

Provenance & Evidence