HCID 67763560, compound → Propylene Oxide

HRID 1654472Notes

Reaction equation

HRID 1654472 reaction equation
Cl.[Cl:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][NH:8][CH2:9][C@H:10]([OH:23])[CH2:11][P:12]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)(=[O:14])[OH:13])=[CH:5][CH:4]=1>C(O)C>[CH2:9]1[O:23][CH:10]1[CH3:11].[Cl:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][NH:8][CH2:9][C@H:10]([OH:23])[CH2:11][P:12]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=2)(=[O:13])[OH:14])=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 67763560HCID 67763560, compound

Product 2

HCID 6378Propylene OxideHCID 18652810HCID 18652810, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner analogous to that described in Preparation Example 2 3-(p-chlorobenzylamino)-2(S)-hydroxy-propyl(p-methylbenzyl)phosphinic acid hydrochloride of m.p. 209°-210° can be manufactured. Dissolution in ethanol and treatment with propylenoxide yields 3-(p-chlorobenzylamino)-2(S)-hydroxy-propyl(p-methylbenzyl)phosphinic acid of m.p. 39,5-241.

Sources & evidence

ORD record
ord-84b72ad4db3140e6af9c9f283826b585
Source dataset
uspto-grants-1995_04
Patent number
US05407922

Reaction notes

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