HCID 67764497, compound → Propylene Oxide

HRID 1654473Notes

Reaction equation

HRID 1654473 reaction equation
Cl.ClC1C=C(C=CC=1Cl)CN[CH2:8][C@H:9]([OH:22])[CH2:10][P:11]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)(=[O:13])[OH:12]>C(O)C>[CH2:8]1[O:22][CH:9]1[CH3:10].[CH3:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][PH:11](=[O:12])[OH:13])=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 67764497HCID 67764497, compound

Product 2

HCID 6378Propylene OxideHCID 178425927HCID 178425927, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner analogous to that described in Preparation Example 3-(3,4-dichlorobenzylamino)-2(S)-hydroxy-propyl(p-methylbenzyl)phosphinic acid hydrochloride can be manufactured. Dissolution in ethanol and treatment with propylenoxide yields 3-(3,4-dichlorobenzylamino)-2(S)-hydroxy-propyl(p-methylbenzyl phosphinic acid of m.p. 222,5°-224°.

Sources & evidence

ORD record
ord-3a2aed5931464348a7bc6b513e5ac871
Source dataset
uspto-grants-1995_04
Patent number
US05407922

Reaction notes

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