Ethylene carbonate → HCID 20078042, compound

Participants

Reaction Steps

To 5-chloro-1-isopropyl-6-nitrobenzimidazol-2-one (1.0 g) were added ethylene carbonate (0.7 g) and phosphorus oxychloride (1.1 ml) and the mixture was refluxed for 5 hours. Phosphorus oxychloride was distilled off under reduced pressure and the residue was dissolved in ethyl acetate and the solution was added to ice-water and the mixture was neutralized with an aqueous sodium hydroxide solution. The organic layer was washed with water and dried over anhydrous magnesium sulfate and then the solvent was distilled off under reduced pressure to give 2,5-dichloro-1-isopropyl-6-nitrobenzimidazole (0.9 g). A part of the obtained product was recrystallized from ethanol, which showed the following physical properties:

Provenance & Evidence