3-Cyanomethyl-1-benzylpyrrolidine hydrochloride → 2-(Pyrrolidin-3-yl)acetonitrile hydrochloride

HRID 1654497Notes

Reaction equation

HRID 1654497 reaction equation
[H][H].[ClH:3].[C:4]([CH2:6][CH:7]1[CH2:11][CH2:10][N:9](CC2C=CC=CC=2)[CH2:8]1)#[N:5]>C(O)C>[ClH:3].[C:4]([CH2:6][CH:7]1[CH2:11][CH2:10][NH:9][CH2:8]1)#[N:5]

Participants

4

Reactant 2

HCID 200781543-Cyanomethyl-1-benzylpyrrolidine hydrochlorideHCID 178418361HCID 178418361, compound

Product 1

HCID 200781392-(Pyrrolidin-3-yl)acetonitrile hydrochlorideYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Catalytic debenzylation, in the presence of hydrogen and palladised carbon, of 3-cyanomethyl-1-benzylpyrrolidine hydrochloride, in ethanol, makes it possible to obtain the desired compound.

Sources & evidence

ORD record
ord-e439dee3a7894ec198d3ce8839d4e3d2
Source dataset
uspto-grants-1995_04
Patent number
US05407946

Reaction notes

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