Isopropyl iodide → HCID 20078086, compound

HRID 1654501Notes

Reaction equation

[SH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=3)[CH:9]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[CH:26](I)([CH3:28])[CH3:27]>>[CH:26]([S:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=3)[CH:9]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1)([CH3:28])[CH3:27]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 20078116HCID 20078116, compound

Product 1

HCID 20078086HCID 20078086, compoundYield 67%

Procedure

Using a similar procedure to that described in Example 1, 4-mercapto-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran was reacted with isopropyl iodide to give 4-isopropylthio-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran in 67% yield, as an oil.

Sources & evidence

ORD record: ord-c4f277b3b7ea4a81ab9f26442e3cc88b
Source dataset: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05407945

Reaction notes

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