HCID 10036403, compound → HCID 10385788, compound

HRID 1654507Notes

Reaction equation

HRID 1654507 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8](=[O:14])[CH:7]=[CH:6]2.[C:15]([C:18]1([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([OH:30])[CH:25]=2)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)(=[O:17])[CH3:16]>>[C:15]([C:18]1([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH2:2][C:3]3[CH:4]=[C:5]4[C:10](=[CH:11][CH:12]=3)[N:9]([CH3:13])[C:8](=[O:14])[CH:7]=[CH:6]4)[CH:25]=2)[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 10036403HCID 10036403, compoundHCID 151990656-(Bromomethyl)-1-methylquinolin-2(1H)-one

Product 1

HCID 10385788HCID 10385788, compoundYield 52%

Procedure

Using a similar procedure to that described in Example 14, 6-bromomethyl-1-methyl-1,2-dihydroquinolin-2-one was reacted with 4-acetyl-4-(3-hydroxyphenyl)tetrahydropyran to give 4-acetyl-4-[3-(1-methyl-2-oxo-1,2-dihydroquinolin-6-ylmethoxy)phenyl]tetrahydropyran in 52% yield, m.p. 125°-126° C.

Sources & evidence

ORD record
ord-a987bf7584ec43e6bb041c1c652970d0
Source dataset
uspto-grants-1995_04
Patent number
US05407945

Reaction notes

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