HCID 10058410, compound → HCID 10090114, compound

HRID 1654508Notes

Reaction equation

HRID 1654508 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8](=[O:14])[CH:7]=[CH:6]2.[OH:15][C:16]1[CH:17]=[C:18]([C:22]2([CH3:28])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1>>[CH3:28][C:22]1([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([O:15][CH2:2][C:3]3[CH:4]=[C:5]4[C:10](=[CH:11][CH:12]=3)[N:9]([CH3:13])[C:8](=[O:14])[CH:7]=[CH:6]4)[CH:17]=2)[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 10058410HCID 10058410, compoundHCID 151990656-(Bromomethyl)-1-methylquinolin-2(1H)-one

Product 1

HCID 10090114HCID 10090114, compoundYield 40%

Procedure

Using a similar procedure to that described in Example 14, 6-bromomethyl-1-methyl-1,2-dihydroquinolin-2-one was reacted with 4-(3-hydroxyphenyl)-4-methyltetrahydropyran to give 4-methyl-4-[3-(1-methyl-2-oxo-1,2-dihydroquinolin-6-ylmethoxy)phenyl]tetrahydropyran in 40% yield, m.p. 107°-108° C.

Sources & evidence

ORD record
ord-5294e27df35b48c39582e0f560c865ae
Source dataset
uspto-grants-1995_04
Patent number
US05407945

Reaction notes

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