HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 7-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| Reactant | tert-Butyl 6-azaspiro[2.5]octan-1-ylcarbamate | HCID 15282171 | — |
| Product | 7-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid | HCID 67553014 | 97% |
Reaction Steps
According to the procedure of example 1A, 1-tert-butoxycarbonylamino-6-azaspiro[2.5]octane (260.0 mg, 1.15 mmol ) and 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (274 mg, 1.04 mmol) were reacted to generate the title product (472 mg, 1.00 mg, 97% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05407943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-2ddc66e1863748aba46743bc164067ec |
| Source note | uspto-grants-1995_04 |