HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 7-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 535414 | — |
| Reactant | tert-Butyl 6-azaspiro[2.5]octan-1-ylcarbamate | HCID 15282171 | — |
| Product | 7-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid | HCID 70347142 | 99.9% |
Reaction Steps
According to the procedure of example 1A, 1-tert-butoxycarbonylamino-6-azaspiro[2.5]octane (181.2 mg, 0.80 mmol) and 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (239.8 mg, 0.72 mmol) were reacted to generate the title product (352.2 mg, crude).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05407943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-7f70ae2e65b8440f9458a53b9f608def |
| Source note | uspto-grants-1995_04 |