HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-(1-Amino-6-azaspiro[2,5]oct-6-yl)-1-cyclopropyl-6,8-difluoro-1,4,-dihydro-4-oxo-quinoline-3-carboxylic acid, hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 7-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid | HCID 70347142 | — |
| Product | 7-(1-Amino-6-azaspiro[2,5]oct-6-yl)-1-cyclopropyl-6,8-difluoro-1,4,-dihydro-4-oxo-quinoline-3-carboxylic acid, hydrochloride salt | HCID 131718965 | 43% |
Reaction Steps
According to the procedure of example 1B, the compound of step A (352.2 mg, crude) was hydrolyzed with hydrochloric acid to provide the title product, mp 241° C. (decomp.), 130.7 mg (0.31 mmol, 43% yield for two steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05407943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-2c968d1506b943b0bab95c33037f7bcc |
| Source note | uspto-grants-1995_04 |