L-Prolinol → HCID 131718966, compound

Participants

Reaction Steps

3-(Indan-2-ylacetyl)-L-thioproline (4.40 g) and L-prolinol (1.53 g) were dissolved in 150 ml of methylene chloride, followed by addition of 2.90 g of WSC-HCl under agitation while cooling in ice and subsequent agitation for-another 30 minutes at room temperature. The reaction solution was washed sequentially in 5 HCl, saturated aqueous solution of sodium bicarbonate, saturated aqueous sodium chloride solution, followed by drying over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by column chromatography to obtain 2.40 g of 1-[3-(indan-2-yl-acetyl)-L-thioprolyl]-L-prolinol. Yield; 42%.

Provenance & Evidence