1-Fluoro-2-nitrobenzene → 2-Phenylethanol

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.03 g of α-amino-2,6-dichlorobenzeneethanol and 0.7 g of 1-fluoro-2-nitrobenzene was stirred for 3 hours at 110° C. The reaction mixture was purified by column chromatography (silica gel; CH2Cl2 /CH3OH 98:2). The eluent of the desired fraction was evaporated and the residue was crystallized from acetonitrile. The product was filtered off and dried, yielding 0.4 g (24.4%) of (±)-2,6-dichloro-β-(2-nitrophenyl)amino]benzeneethanol; m.p. 127.6° C. (comp. 12).

Provenance & Evidence