Sodium Hydroxide → HCID 15279027, compound

HRID 1654613Notes

Reaction equation

HRID 1654613 reaction equation
[SH:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[OH-].[Na+].[F:10][C:11]1[C:18]([F:19])=[C:17]([F:20])[C:16]([F:21])=[C:15]([F:22])[C:12]=1[CH2:13]Br>C(O)C>[F:10][C:11]1[C:18]([F:19])=[C:17]([F:20])[C:16]([F:21])=[C:15]([F:22])[C:12]=1[CH2:13][S:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 74484Pentafluorobenzyl bromideHCID 178418793HCID 178418793, compound

Product 1

HCID 15279027HCID 15279027, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 0.47 g of 2-mercapto-pyrimidine in 15 ml 95% ethanol was added 0.18 g of NaOH. The mixture was stirred 45 min. until an amber solution resulted; then 1 g of 2,3,4,5,6-pentafluorobenzyl bromide was added. The adduct precipitated within five minutes. Stirring continued for one hour. Filtration of the mixture yielded 0.26 g, mp 89°-92° C.

Workup

  1. customresulted
  2. customThe adduct precipitated within five minutes
  3. stirringStirring
  4. waitcontinued for one hour
  5. filtrationFiltration of the mixture
  6. customyielded 0.26 g, mp 89°-92° C.

Sources & evidence

ORD record
ord-99752190709546d994043c319b94a656
Source dataset
uspto-grants-1995_04
Patent number
US05409809

Reaction notes

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