Water → 2-(2,3,4,5,6-Pentafluoro-benzylsulfanyl)-1H-benzoimidazole

Participants

Reaction Steps

To a slurry of 1.50 g of the 2-mercaptobenzimidazole in 28.5 ml of 95% ethanol was added 0.4 g of sodium hydroxide. After all materials had dissolved, the mixture was added to 2.80 g of 2,3,4,5,6-pentafluorobenzyl bromide. The mixture was stirred at 28°-32° C. for 1 hr, then poured into 150 ml water. The product precipitated, was filtered and dried to yield 2.50 g, mp 189°-196° C. Recrystallization from aqueous methanol yielded 1.95 g, mp 193°-195° C.

Provenance & Evidence