Toluene → HCID 15240672, compound

Participants

Reaction Steps

To 15 ml of toluene were added 2.2 g of N-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-N-(1-methyl-2-oxopropyl)-2-phenylacetamide and 3.5 g of 1,8-diazabicyclo[5.4.0]undecene-7 (DBU), followed by stirring at room temperature for 1 hour. After water was added, the solution was extracted with ethyl acetate, and then dried over anhydrous sodium sulfate. After the solvent was distilled off, the solution was subjected to silica gel column chromatography to obtain 1.1 g of the desired 1-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-4,5-dimethyl-3-phenyl-3-pyrroline-2-one.

Provenance & Evidence