Water → HCID 15240665, compound

Participants

Reaction Steps

In 30 ml of dichloromethane containing 4.0 g of pyridine, 5.0 g of 2-(2-fluorophenyl)acetyl chloride was added dropwise to 3.2 g of N-[1-methyl-1-(3-chlorophenyl)ethyl]-N-(1-methyl-2-oxopropyl)amine at 20° to 30° C. After stirring for 1 hour, the solution was poured into water, and then extracted with dichloromethane. Next, the solution was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, concentrated by an evaporator, and then subjected to column chromatography to obtain 2.4 g of N-[1-methyl-1-(3chlorophenyl)ethyl]-N-(1-methyl-2-oxopropyl)-2-(2-fluorophenyl)acetamide.

Provenance & Evidence