Benzenesulfonic Acid → HCID 178494567, compound

Participants

Reaction Steps

A solution of 0.44 g (1 eq. ) of benzenesulfonic acid in 9 ml of ethyl acetate was added dropwise to a solution of 1.5 g (2.77 mmol) of α-(2,2-dimethylpropanoyloxy)ethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-methoxymethyl-3-cephem-4-carboxylate in 21 ml of ethyl acetate. After crystallization began, the mixture was stirred for a further 30 minutes, and the crystals were filtered off with suction and washed with a little diethyl ether. After drying over CaCl2 /paraffin in vacuo, 1.4 g of the desired title compound were obtained, which was identified as crystalline material under the polarization microscope and consisted of an approximately 1:1 mixture of the two diastereomers according to HPLC.

Provenance & Evidence