p-Toluenesulfonic acid → HCID 178494566, compound

Participants

Reaction Steps

A solution of 2.1 g (11 mmol ) of p-toluenesulfonic acid in 5 ml of ethanol was added dropwise to a solution of 5 g (9.3 mmol) of α-(2,2-dimethylpropanoyloxy)ethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-methoxymethyl-3-cephem-4-carboxylate in 32 ml of ethanol. After stirring at room temperature for 30 minutes, a total of 280 ml of diisopropyl ether were added to the crystal magma formed and the mixture was briefly stirred. The precipitate formed was then filtered off with suction and washed with a little diisopropyl ether, and the residue was dried in vacuo over calcium chloride/paraffin. 5.4 g of the desired crystalline title compound were obtained, which consisted of an approximately 1:1 mixture of the two diastereomers according to HPLC and was identical in its physical and chemical properties with the product from working example 2.

Provenance & Evidence