反应详情

温度

150 °C

To 20 ml of methanol is dissolved 2.8 g of 2-dimethylaminoethanethiol. To this, 20 ml of 2M solution of sodium methoxide in methanol and 3 g of 6-chloroimidazo-[1,2-b]pyridazine are added successively and the mixture is heated in a sealed tube for 4 hours at 150° C. After cooling, the solvent is evaporated and the residue is treated with water. The mixture is then extracted with methylene chloride. The organic layer is separated, washed with saturated aqueous solution of sodium chloride and dried over MgSO4. Evaporation of the solvent gives 2.5 g of the title compound as pale yellow crystals.

1. temperatureAfter cooling
2. customthe solvent is evaporated
3. additionthe residue is treated with water
4. extractionThe mixture is then extracted with methylene chloride
5. customThe organic layer is separated
6. washwashed with saturated aqueous solution of sodium chloride
7. dry with materialdried over MgSO4
8. customEvaporation of the solvent