反应详情

温度

-20 °C

To a solution of 218 mg of phosphorus pentachloride in 3 ml of methylene chloride, 202 mg of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxyiminoacetic acid is added under cooling at -20° C. with stirring and the mixture is stirred for half an hour at -20° C. and for two hours at -5° C. The reaction mixture in concentrated under reduced pressure and the residue is triturated with 10 ml of hexane. The precipitate is collected by filtration to give 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxyiminoacetyl chloride hydrochloride.

1. stirringthe mixture is stirred for half an hour at -20° C. and for two hours at -5° C
2. concentrationThe reaction mixture in concentrated under reduced pressure
3. customthe residue is triturated with 10 ml of hexane
4. filtrationThe precipitate is collected by filtration