HCID 15780053, compound → HCID 15780051, compound

HRID 1654666Notes

Reaction equation

HRID 1654666 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([CH2:14][CH3:15])[N:8]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]3[N:33]([C:34]([C:47]4[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=4)([C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)[C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[N:32]=[N:31][N:30]=3)=[CH:19][CH:18]=1)[C:7]2=[O:53])([O-])=O>O1CCOCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([CH2:14][CH3:15])[N:8]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]3[N:33]([C:34]([C:47]4[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=4)([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)[C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[N:32]=[N:31][N:30]=3)=[CH:21][CH:22]=1)[C:7]2=[O:53]

Participants

4

Reactant 1

HCID 15780053HCID 15780053, compound

Product 1

HCID 15780051HCID 15780051, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

6-Nitro-2-ethyl-3-[(2'-(N-triphenylmethyltetrazol-5-yl)-biphen-4-yl)-methyl]-quinazolin-4(3H)-one (0.11 g) was hydrogenated in dioxane (2.0 ml) solution under 1 atm H2 for 1 hr in the presence of Raney nickel catalyst.

Workup

  1. customfor 1 hr

Sources & evidence

ORD record
ord-8a08783a4e584e58bc910e946330c2a1
Source dataset
uspto-grants-1995_04
Patent number
US05409926

Reaction notes

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