HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl chloroformate → 1-(1,4-Dioxaspiro[4.5]dec-7-ylcarbonyl)-4-(2-pyridinyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decane-7-carboxylic acid | HCID 567492 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(1,4-Dioxaspiro[4.5]dec-7-ylcarbonyl)-4-(2-pyridinyl)piperazine | HCID 20076682 | 58.2% |
Reaction Steps
From 1,4-dioxaspiro[4.5]decane-7-carboxylic acid (Example A, Step A) (10 g), triethylamine (8 g), isobutyl chloroformate (7.9 g) and 1-(2-pyridyl)piperazine (8.3 g) using the procedure of Example A, Step B is obtained 9.8 g of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409931 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-f1c6b956f4934b0e9051006fce9d92e7 |
| Source note | uspto-grants-1995_04 |