Hydrogen Peroxide → HCID 70065773, compound

Participants

Reaction Steps

(±)-β-[[5-[4-(Aminoiminomethyl)phenyl]-1-oxopentyl]amino]-2-(methylsulfinyl)benzenepropanoic acid (2.5 g) was added to water (15 ml), acetic acid (5 ml) and followed by the addition of 30% H2O2 (10 mL). The oxidation was allowed to proceed for 48 hours after which the reaction mixture was purified by reverse phase chromatography (water/acetonitrile) and lyophilized to give 1.6 g of the title compound as a white solid: 1H NMR (d6 -DMSO) δ1.52 (m, 4H), 2.01 (m, 2H), 2.63 (m, 4H), 3.50 (s, 3H), 5.82 (m, 1H), 7.35 (m, 9H), 7.7 (m, 1H), 9.10 (bs, 2H), 9.20 (bs, 2H); MS (FAB) m/e 446.2 (M+H+).

Provenance & Evidence