Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ciprofloxacin | HCID 2764 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 13340206 | HCID 13340206 | 97.4% |
Reaction Steps
3.31 g of 1-cyclopropyl-6-fluoro-7-(piperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid was dissolved in a mixture of 30 ml of methanol and 20 ml of chloroform, and the resulting solution was stirred at 50° C. for 5 hours after addition of 2.29 g of di-t-butylcarbonate thereto. The solvent was removed under reduced pressure to obtain 4.2 g of the object compound
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05409933 |
|---|
| Source dataset | uspto-grants-1995_04 |
|---|
| ORD ID | ord-16bace35f918439f999c1d61d4bd017f |
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| Source note | uspto-grants-1995_04 |
|---|
