Water → HCID 20076721, compound

HRID 1654749Notes

Reaction equation

HRID 1654749 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:27])=[C:11]([N:14]4[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:28])[C:6]([C:29](=[O:41])[CH:30](C(OCC)=O)[C:31]([O:33][CH2:34][CH3:35])=[O:32])=[CH:5]2)[CH2:3][CH2:2]1.O.[ClH:43].CO>>[ClH:43].[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:27])=[C:11]([N:14]4[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]4)[CH:12]=3)[C:7](=[O:28])[C:6]([C:29](=[O:41])[CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])=[CH:5]2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 962WaterHCID 20076757HCID 20076757, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 20076721HCID 20076721, compoundYield 62%

Procedure

5.74 g of the compound obtained from Example 17 was dissolved in 200 ml of 5% HCl-methanol solution, and then 0.5 ml of distilled water was added thereto. This solution was stirred at room temperature for 24 hours. The solvent was distilled off and concentrated under reduced pressure. 20 ml of acetone and 100 ml of diethyl ether were added thereto, and the resulting solid was filtered and then dried to obtain 2.71 g of the object compound

Workup

  1. distillationThe solvent was distilled off
  2. concentrationconcentrated under reduced pressure
  3. addition20 ml of acetone and 100 ml of diethyl ether were added
  4. filtrationthe resulting solid was filtered
  5. customdried

Sources & evidence

ORD record
ord-65ce59d8e03543a889d64306e8a4911f
Source dataset
uspto-grants-1995_04
Patent number
US05409933

Reaction notes

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