Ethyl cyanoacetate → HCID 20076790, compound

HRID 1654752Notes

Reaction equation

[N-]1C=CN=C1.[CH:6]1([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:35])=[C:16]([N:20]4[CH2:24][CH:23]=[C:22]([CH2:25][N:26](C(OC(C)(C)C)=O)[CH3:27])[CH2:21]4)[C:17]=3[Cl:19])[C:12](=[O:36])[C:11]([C:37](O)=[O:38])=[CH:10]2)[CH2:8][CH2:7]1.[C:40]([CH2:42][C:43]([O:45][CH2:46][CH3:47])=[O:44])#[N:41]>>[ClH:19].[CH:6]1([N:9]2[C:18]3[C:13](=[CH:14][C:15]([F:35])=[C:16]([N:20]4[CH2:24][CH:23]=[C:22]([CH2:25][NH:26][CH3:27])[CH2:21]4)[C:17]=3[Cl:19])[C:12](=[O:36])[C:11]([C:37](=[O:38])[CH:42]([C:40]#[N:41])[C:43]([O:45][CH2:46][CH3:47])=[O:44])=[CH:10]2)[CH2:8][CH2:7]1

Participants

Reactant 2

HCID 7764Ethyl cyanoacetate

HCID 86748638HCID 86748638, compound

Product 1

HCID 20076790HCID 20076790, compoundYield 103.1%

Procedure

5.8 g of 1-cyclopropyl-6-fluoro-8-chloro-7-(3-(N-methyl-t-butoxycarbonylamino)methyl-2,5-dihydropyrrol-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid imidazolide and 5.66 g of ethyl cyanoacetate as starting materials were subjected to the same process as described in Example 39 to obtain 2.80 g of the object compound

Sources & evidence

ORD record: ord-9fef3fa6a14645e698288b681e448fc1
Source dataset: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05409933

Reaction notes

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