HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | Lithium bis(trimethylsilyl)amide | HCID 57426343 | — |
| Reactant | HCID 178462446 | HCID 178462446 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol | HCID 2760416 | — |
Reaction Steps
In step a, trimethylsilylacetylene (1) can first be reacted with a non-nucleophilic base, such as lithium hexamethyldisilazane, in a suitable aprotic solvent, such as tetrahydrofuran. The resulting lithium acetylide can then be reacted with the appropriate benzaldehyde compound of structure 2 to give the corresponding α-[(trimethylsilyl)ethynyl]-benzenemethanol compound of structure 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409942 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-a4bd6d5991e44ca787171a8d519a9802 |
| Source note | uspto-grants-1995_04 |