HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → HCID 11447136, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | alpha-Ethynylbenzenemethanol | HCID 20155 | — |
| Reactant | 3-Bromopyridine hydrochloride | HCID 522174 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | HCID 11447136 | HCID 11447136 | — |
Reaction Steps
Place 3-bromopyridine hydrochloride (0.78 g, 4 mmol), α-(ethynyl)-benzenemethanol (661 mg, 5 mmol) and diethylamine (25 mL) under nitrogen atmosphere. Add bis(triphenylphosphine)palladium(II) chloride (140 mg) then copper(I) iodide (20 mg). Stir overnight at room temperature and filter. Evaporate the solvent in vacuo and filter through silica gel (2:1 ethyl acetate/hexane). Evaporate the solvent in vacuo and recrystallize (25% ethyl acetate/hexane) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409942 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-e035492464a04b19a0f0504955336aba |
| Source note | uspto-grants-1995_04 |