HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-Phenyl-3-(2-furanyl)-2-propyne-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Cornforth reagent | HCID 2724130 | — |
| Reactant | alpha-[(2-Furanyl)ethynyl]-benzenemethanol | HCID 20076917 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-Phenyl-3-(2-furanyl)-2-propyne-1-one | HCID 14401734 | — |
Reaction Steps
Place pyridinium dichromate (0.75 g, 2 mmol) and methylene chloride (15 mL) under argon atmosphere and cool to 0° C. Add α-[(2-furanyl)ethynyl]-benzenemethanol (297 mg, 1.5 mmol). Stir overnight while slowly warming to room temperature. Dilute with ethyl ether and filter the chromium salts. Purify by silica gel chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409942 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-a42f66b7f987487399e9614f7813cf37 |
| Source note | uspto-grants-1995_04 |