HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1654781Generated: October 25, 2026
Hydrochloric Acid → 5-amino-6-bromo-1-indanone
https://huagongshe.com/reaction/1654781
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(6-Bromo-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide | HCID 9993147 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-amino-6-bromo-1-indanone | HCID 10398776 | — |
Reaction Steps
A mixture of 5-acetylamino-6-bromo-l-indanone (36.0 g, 0.13 mmol) and 6M aqueous hydrochloric acid (800 mL) was refluxed for 1 h. The homogenous solution was then cooled to 0° C. and adjusted to pH 8 with 10M aqueous NaOH (~480 mL). The precipitate formed was collected, washed with water and dried under vacuum to afford 30.0 g (quantitative) of the title compound as a light brown powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05409944 |
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| Source dataset | uspto-grants-1995_04 |
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| ORD ID | ord-170f2aafd17b40bdb76d5cb48065bb70 |
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| Source note | uspto-grants-1995_04 |
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