Acetic Acid → HCID 14985924, compound

Participants

Reaction Steps

2.6 g (53 mmol) of sodium cyanide and then 18.50 g (223 mmol, 25 eq.) of activated manganese dioxide are added to 2 g (8.5 mmol) of 6-formyl-7-hydroxy-5-methoxy-2-methyl-4H -benzopyran-4-one (A. SCHONBERG, N. BADRAN and N. A. STARKONSKY, J. Am. Chem. Soc., 1953, 75, 4992) suspended in 105 ml of methanol acidified with 2.6 ml of acetic acid. After having been stirred for 4 hours at room temperature, the reaction mixture, diluted with 200 ml of ethyl acetate, is filtered to remove insoluble material (excess MnO2) and the solvents are evaporated. The powdery residue is taken up in water and filtered. 1.80 g of a beige powder are obtained.

Provenance & Evidence