反应详情

A mixture of 2-amino-3-benzyloxypyridine (2.5 g, 12.5 mmol) and ethyl phenylacetimidate hydrochloride (2.5 g, 12.5 mmol) in ethanol (100 ml) was heated under reflux for 1 hour. The solvent was evaporated in vacuo, and the residue taken up in chloroform, washed with aqueous sodium bicarbonate, dried and the chloroform evaporated. Treatment with charcoal and recrystallisation from ethyl acetate/petroleum ether gave the product (0.62 g), m.p. 114°-116° C.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. customThe solvent was evaporated in vacuo
4. washwashed with aqueous sodium bicarbonate
5. customdried
6. customthe chloroform evaporated
7. customTreatment with charcoal and recrystallisation from ethyl acetate/petroleum ether