反应详情

A mixture of 2-amino-3-(2-methylbenzyloxy)pyridine (5.2 g, 24.2 mmol) and ethyl phenylacetimidate hydrochloride (5.32 g, 26.7 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was taken up in chloroform, filtered to remove an insoluble white solid, and purified by flash chromatography (chloroform/methanol) to obtain the product (0.85 g), m.p. 175°-178° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. customEvaporation of the solvent
4. customgave an oil which
5. filtrationfiltered
6. customto remove an insoluble white solid
7. custompurified by flash chromatography (chloroform/methanol)