HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(2-Methylphenyl)methoxy]pyridin-2-amine → HCID 178424274, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(2-Methylphenyl)methoxy]pyridin-2-amine | HCID 13825882 | — |
| Reactant | Ethyl 2-(2-methylphenyl)ethanimidate--hydrogen chloride (1/1) | HCID 20076957 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178424274 | HCID 178424274 | 14.8% |
Reaction Steps
A mixture of 2-amino-3-(2-methylbenzyloxy)pyridine (5.2 g, 24.2 mmol) and ethyl 2-methylphenylacetimidate hydrochloride (5.7 g, 26.7 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was purified by flash chromatography (chloroform/methanol) to obtain the product (1.37 g), m.p. 147°-154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-6be8a98d39094128ba932bdc6e62d7ee |
| Source note | uspto-grants-1995_04 |