反应详情

A mixture of 2-amino-3-(2-methylbenzyloxy)pyridine (5.2 g, 24.2 mmol) and ethyl 4-methoxyphenylacetimidate hydrochloride (6.1 g, 26.7 mmol) in ethanol (80 ml) was heated under reflux for 2 hours, then the solvent evaporated. The residue was taken up in chloroform, filtered to remove an insoluble solid, and the filtrate purified by flash chromatography (chloroform/methanol) to obtain the product (0.29 g), m.p. 58°-67° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. customthe solvent evaporated
4. filtrationfiltered
5. customto remove an insoluble solid
6. customthe filtrate purified by flash chromatography (chloroform/methanol)