HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 13780008, compound → HCID 178424277, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 13780008 | HCID 13780008 | — |
| Reactant | 3-[(2-Methylphenyl)methoxy]pyridin-2-amine | HCID 13825882 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178424277 | HCID 178424277 | 5.2% |
Reaction Steps
A mixture of 2-amino-3-(2-methylbenzyloxy)pyridine (5.2 g, 24.2 mmol) and ethyl 4-fluorophenylacetimidate hydrochloride (5.8 g, 26.7 mmol) in ethanol (80 ml) was heated under reflux for 2 hours, then the solvent evaporated. The residue was purified by flash chromatography (chloroform/methanol) to obtain the product as a foam (0.49 g), m.p. 59°-64° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-7e91ce0698394820841927184fb6d7a2 |
| Source note | uspto-grants-1995_04 |