反应详情

A mixture of 2-amino-3-(4-methoxybenzyloxy)pyridine (4.6 g, 20 mmol) and ethyl 2methylphenylacetimidate hydrochloride (4.69 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was taken up in chloroform, convened to the free base by washing with aqueous sodium bicarbonate, and purified by flash chromatography (chloroform/methanol) to obtain the product as a gum (0.38 g).

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. customEvaporation of the solvent
4. customgave an oil which
5. washby washing with aqueous sodium bicarbonate
6. custompurified by flash chromatography (chloroform/methanol)