2-Amino-3-(2,6-dichlorobenzyloxy)pyridine → HCID 178479198, compound

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Reaction Steps

A mixture of 2-amino-3-(2,6-dichlorobenzyloxy)pyridine (5.38 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was purified by flash chromatography (chloroform/methanol) to obtain the product as a hygroscopic foam (1.52 g), m.p. 69°-74° C.

Provenance & Evidence