HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-(2-fluorobenzyloxy)pyridine → N'-[3-[(2-fluorophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamide;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-(2-fluorobenzyloxy)pyridine | HCID 10242491 | — |
| Reactant | Ethyl 2-phenylacetimidate hydrochloride | HCID 12218775 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N'-[3-[(2-fluorophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamide;hydrochloride | HCID 178479194 | 4.8% |
Reaction Steps
A mixture of 2-amino-3-(2-fluorobenzyloxy)pyridine (4.36 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was purified by flash chromatography (chloroform/methanol) and recrystallisation from ethanol/ether to obtain the product (0.36 g), m.p. 160°-165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-0879767a7f5846faa26d135f01156aab |
| Source note | uspto-grants-1995_04 |