HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-(2-chloro-6-fluorobenzyloxy)pyridine → HCID 178479190, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-(2-chloro-6-fluorobenzyloxy)pyridine | HCID 10106270 | — |
| Reactant | HCID 12283339 | HCID 12283339 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178479190 | HCID 178479190 | — |
Reaction Steps
A mixture of ethyl 2-chlorophenylacetimidate hydrochloride (5.07 g, 0.0216 mol), 2-amino-3-(2-chloro-6-fluorobenzyloxy)pyridine (4.95 g, 0.0196 mol)and ethanol (150 ml) was heated under reflux for 2 hours. The solvent was evaporated off and the resultant oil was purified by chromatography (silica gel, 1% methanol/dichloromethane) and trituration with ether. Yield 0.7 g (8%), m.p. 156°-158 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-a22a4c767e824042b67a6522426f9f56 |
| Source note | uspto-grants-1995_04 |