Ammonia → HCID 178512022, compound

HRID 1654863Notes

Reaction equation

HRID 1654863 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=S)=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:26]>>[CH2:1]([O:8][C:9]1[C:10]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)=[NH:26])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077013HCID 20077013, compound

Product 1

HCID 178512022HCID 178512022, compound

Procedure

To a stirring suspension of N-(3-benzyloxy-2-pyridyl)-N'-(4-chlorophenyl)thiourea (1.5 g, 0.00406 mol) in ammonia-saturated methanol (30 ml) was added yellow mercuric oxide (2.2 g, 0.01 mol). Stirring was continued for 20 h, then the solvent evaporated and the black residue treated with chloroform and filtered through celite. The filtrate was evaporated to a whim solid, which was recrystallised from ethyl acetam. Yield 0.76 g (53%), m.p. 170°-172 ° C.

Workup

  1. customthe solvent evaporated
  2. additionthe black residue treated with chloroform
  3. filtrationfiltered through celite
  4. customThe filtrate was evaporated to a whim solid, which
  5. customwas recrystallised from ethyl acetam

Sources & evidence

ORD record
ord-2afec427a72e4aa8b7bf5daca6099b3e
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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