Ammonia → HCID 178512014, compound

HRID 1654867Notes

Reaction equation

HRID 1654867 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)=S)=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:29]>>[CH2:1]([O:8][C:9]1[C:10]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)=[NH:29])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 20077002HCID 20077002, compound

Product 1

HCID 178512014HCID 178512014, compound

Procedure

A mixture of N-(3-benzyloxypyrid-2-yl)-N'-(4-trifluoromethylphenyl)thiourea (3.08 g, 0.0076 mol), yellow mercuric oxide (2 g, 0.0092 mol) and methanolic ammonia solution (40 ml) was stirred for 48 hours at room temperature, then the solvent was removed in vacuo and the residue extracted with boiling chloroform and filtered hot. Evaporation of the filtrate and recrystallisation from acetonitrile gave the desired product. Yield 2.05 g (70%), m.p. 154°-155 ° C.

Workup

  1. customthe solvent was removed in vacuo
  2. extractionthe residue extracted with boiling chloroform
  3. filtrationfiltered hot
  4. customEvaporation of the filtrate and recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-405704181fa74a1e9b7facb8a679b630
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

Loading…