HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-[3-(2-Methylbenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | 3-[(2-Methylphenyl)methoxy]pyridin-2-amine | HCID 13825882 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[3-(2-Methylbenzyloxy)pyrid-2-yl]-N'-(4-chlorophenyl)thiourea | HCID 20077040 | — |
Reaction Steps
A mixture of 2-amino-3-(2-methylbenzyloxy)pyridine (1.19 g, 0.0056 mol), 4-chlorophenyl isothiocyanate (1.15 g, 0.0068 mol) and toluene (10 ml) was refluxed for 2.5 hours, then cooled and treated with ether to induce crystallisation of the product. Yield 1.63 g (77%), m.p. 181°-183 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-cf3a877fdba34dfdb85e92becbb0ed01 |
| Source note | uspto-grants-1995_04 |